Cancer is one of the leading causes of mortality and morbidity around the world including in India. The situation in India is somewhat grim mainly due to high treatment costs and unawareness. The most commonly used therapy for treatment includes chemotherapy and radiotherapy both of which do not specifically target cancer cells rather in many instances, they lead to enrichment of drug and radio-resistant cells which may lead to tumor recurrences. Immunotherapy is somewhat targeted to the tumor cell but is prohibitively costly. But non of the current drugs present in the market target cancer stem cells which have the potency to regenerate the entire tumor mass leading to tumor relapse. In this scenario, the need of the hour is an affordable targeted therapy option that can target cancer cells as well as the drug-resistance cancer stem cells. Our autologous engineered exosomes provides an affordable targeted therapy platform that if successful will revolutionize cancer treatment not only in India but also other developing economies. We will harvest autologous exosomes which will be bioengineered to carry chemotherapeutic drugs specifically to the cancer cells and cancer stem cells. This could then achieve maximal elimination of cancer cells with minimal side effects and a prolonged RFS.